OFF-TARGET EFFECTS IN CRISPR/CAS9 GENE EDITING

Gene editing stands for the methods to precisely make changes to a specific nucleic acid sequence.With the recent development of the clustered regularly interspaced short palindromic repeats (CRISPR)/Cas9 system, gene editing has become efficient, convenient and programmable, leading to promising translational studies and clinical trials for both S

Tiffany Dong,* Ben Alencherry,* Susan Ospina, Milind Y Desai Section Vibrating Dildos of Cardiovascular Imaging, Heart, Vascular and Thoracic Institute, Cleveland Clinic, Cleveland, OH, USA*These authors contributed equally to this workCorrespondence: Milind Y Desai, Department of Cardiovascular Medicine, Miller Family Heart and Vascula